Marco Pirazzini Selected Research

Neurotoxins

4/2022	Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody.
1/2022	Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
11/2021	Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice.
1/2021	Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets.
11/2019	The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs.
7/2018	Preparation of Cerebellum Granule Neurons from Mouse or Rat Pups and Evaluation of Clostridial Neurotoxin Activity and Their Inhibitors by Western Blot and Immunohistochemistry.
6/2018	Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.
1/2018	Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls.
1/2017	Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.
1/2017	CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.

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Marco Pirazzini Research Topics

Disease

16	Tetanus 04/2022 - 11/2011
13	Botulism 01/2022 - 12/2011
8	Paralysis (Palsy) 01/2021 - 11/2011
2	Muscle Spasticity (Spastic) 11/2021 - 01/2021
2	Wounds and Injuries (Trauma) 01/2021 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2020
1	X-Linked Bulbo-Spinal Atrophy 01/2020
1	Atrophy 01/2020
1	Body Weight (Weight, Body) 01/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2020
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2020
1	Pathologic Processes 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Inflammation (Inflammations) 01/2019
1	Dystonia (Limb Dystonia) 08/2017
1	Pain (Aches) 01/2017
1	Nervous System Diseases (Neurological Disorders) 12/2015
1	Neoplasms (Cancer) 05/2011

Drug/Important Bio-Agent (IBA)

17	Botulinum Toxins (Botulinum Toxin)IBA 04/2022 - 11/2011
13	NeurotoxinsIBA 04/2022 - 01/2013
6	SNARE Proteins (SNAREs)IBA 01/2022 - 01/2013
6	Proteins (Proteins, Gene)FDA Link 11/2021 - 11/2011
3	Metalloproteases (Metalloproteinases)IBA 04/2022 - 01/2021
3	tetanospasmin (tentoxilysin)IBA 11/2021 - 01/2021
3	DisulfidesIBA 11/2019 - 11/2011
2	Peptides (Polypeptides)IBA 04/2022 - 01/2020
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 05/2017
2	ExotoxinsIBA 11/2021 - 11/2019
2	Qa-SNARE Proteins (Syntaxin)IBA 12/2017 - 08/2017
2	incobotulinumtoxinA FDA Link 12/2015 - 08/2013
2	Pharmaceutical PreparationsIBA 12/2015 - 05/2011
2	ThioredoxinsIBA 09/2014 - 01/2013
2	Thioredoxin-Disulfide ReductaseIBA 09/2014 - 01/2013
1	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 04/2022
1	rimabotulinumtoxinB FDA Link 04/2022
1	AntibodiesIBA 11/2021
1	EpitopesIBA 11/2021
1	Therapeutic UsesIBA 11/2021
1	Monoclonal AntibodiesIBA 11/2021
1	Formaldehyde (Formol)FDA Link 11/2021
1	Immunoglobulins (Immunoglobulin)IBA 11/2021
1	Hazardous Substances (Hazardous Materials)IBA 07/2021
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021
1	gamma-Aminobutyric Acid (GABA)IBA 01/2021
1	polyglutamineIBA 01/2020
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA 01/2020
1	ebselenIBA 11/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	LigandsIBA 01/2019
1	N-Ethylmaleimide-Sensitive Proteins (N-Ethylmaleimide-Sensitive Fusion Protein)IBA 07/2018
1	Botulinum AntitoxinIBA 01/2018
1	Oxidoreductases (Dehydrogenase)IBA 09/2014
1	Type A Botulinum Toxins (Botox)FDA Link 08/2013
1	botulinum toxin type DIBA 05/2013
1	AcidsIBA 05/2011
1	MicellesIBA 05/2011
1	LipidsIBA 05/2011
1	Paclitaxel (Taxol)FDA LinkGeneric 05/2011
1	polyethylene glycol- distearoylphosphatidylethanolamineIBA 05/2011

Therapy/Procedure

5	Therapeutics 11/2021 - 08/2013
1	Muscle Denervation 01/2020